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Sunlight and Its Bioregulatory Effects on Human Physiology


The earth has been bathing in sunlight for more than 3 billion years. The sun produces an enormous amount of energy including cosmic rays, gamma rays, x-rays, ultraviolet radiation, visible radiation and infrared radiation. Ordinarily, sunlight is broken down into three major components:

(1) visible light, with wavelengths between 0.4 and 0.8 micrometre,

(2) ultraviolet light, with wavelengths shorter than 0.4 micrometre, and

(3) infrared radiation, with wavelengths longer than 0.8 micrometre.

The Electromagnetic Spectrum

Most of the ultraviolet radiation is efficiently absorbed by the stratospheric ozone layer; however, some reaches the earth, and with other penetrating solar rays, is essential to life and optimal health. Although ultraviolet light constitutes only a very small proportion of the total radiation that reaches the earth’s surface, this component is extremely important for our health. It produces vitamin D through the activation of ergosterol and plays a role in several other important bioregulatory processes in the body.

The healing power of the sun and its use in medical treatment (heliotherapy) have roots extending back into antiquity. Many traditional medical systems (Egyptian, Greek, Romans, Chinese, etc.) have recognized sunlight as a therapeutic force for millennia. In the modern era, particularly the first half of the 20th century, heliotherapy was widely used in both Europe and North America.

Cultural Changes Affecting Sunlight Exposure

Over time, clothing became the norm in higher latitudes and then eventually a social attribute in many societies. By the 1600s, peoples in these regions covered their whole body, even in summertime. As the industrial revolution swept across Northern Europe in the early 19th century, physicians began reporting that children living in the inner cities of Glasgow and London were developing skeletal deformities especially prominent in the legs as well as growth retardation. By the turn of the 19th century, it was estimated that more than 90% of children living in the industrial cities throughout Europe had this bone deformity disease known as rickets.1

In 1822, Sniadecki reported that children living in Warsaw were afflicted with rickets whereas children living in the rural areas outside of Warsaw did not develop this bone deformity disease. He concluded, “strong and obvious is the influence of sun on the cure of rickets and the frequent occurrence of the disease in densely populated towns where the streets are narrow and poorly lit”.2

It was inconceivable to the medical community of that time how exposure of the skin to sunlight could have any health consequences on the skeleton or disease. Consequently, this observation was ignored for almost 100 years.

Typical living conditions in the Gorbals in 1912. This region of Glasgow was the most notorious slum in the United Kingdom. (Mitchell Library, Glasgow Life)

Typical living conditions in the Gorbals in 1912. This region of Glasgow was the most notorious slum in the United Kingdom. (Mitchell Library, Glasgow Life)

In 1890, Theobald Palm, a medical missionary, wrote to his colleagues living in India and China where nutrition was extremely poor, asking whether they were seeing children with rickets. They reported that it was a rare condition in these countries. He reasoned that children living in London had better nutrition and better housing conditions, and therefore the only common denominator was that children living in the polluted cities of London and Glasgow were not exposed to adequate sunlight. He encouraged sunbathing as a method to treat and prevent rickets. While Palm’s observations were in some ways anecdotal, they had a potent effect on the development of photobiology.3

About that same time in 1893, Niels Ryberg Finsen published a paper about the effects of light on skin. Finsen suffered from Niemann-Pick disease, and noted that his own sluggishness seemed cured with a regular daily dose of sunlight. This inspired him to investigate the effects of light on living things. Finsen discovered that certain wavelengths of light can generate healing properties and was eventually able to demonstrate its effects on a skin condition called lupus vulgaris. He also showed that solar radiation could help treat smallpox and tuberculosis. Finsen won the Nobel Prize in Physiology in 1903 for his work on phototherapy.4, 5, 6

Finsen won the Nobel Prize in Physiology in 1903 for his work on phototherapy.

In 1895, Finsen founded the Finsen Institute for Phototherapy in Copenhagen, which was dedicated to studying the effects of light or phototherapy on health conditions. There were at least 800 lupus vulgaris patients treated at the Institute. Of those patients, at least half were cured.

Doctors throughout Europe and North America began promoting whole-body sunbathing to help prevent rickets. It was also recognized that wintertime sunlight in the temperate zone was too feeble to prevent rickets. For this reason, many children were exposed to UVR from a mercury or carbon arc lamp for one hour three times a week, which proved to be an effective preventive measure and treatment.

Around the time the solar solution to rickets gained widespread recognition in medical circles, another historic scourge, tuberculosis (TB), was also found to respond to solar intervention. TB patients of all ages were sent to rest in sunny locales and generally returned in good health.

Sunlight therapy, or heliotherapy, became even more popular after a Swiss doctor, Auguste Rollier, began using it in the early 1900s.

Sunlight therapy, or heliotherapy, became even more popular after a Swiss doctor, Auguste Rollier, began using it in the early 1900s. Inspired by Finsen, Rollier enthusiastically opened “solaria” throughout Switzerland.7 These were buildings designed to optimize exposure to the sun’s rays. Soon, buildings, all with south-facing balconies and some with sliding walls of windows and retractable roofs, were built across Europe. Rollier devised a detailed protocol for how, exactly, to sunbathe for health. He was convinced that early-morning sun was best, and that sun exposure was most beneficial when the air was cool. When patients, most of whom had tuberculosis, arrived at his solaria, they first had to adjust to the altitude (his clinics were in the mountains), and then to the cool air. Once acclimated, Rollier slowly exposed them to the sun. 8, 9

Soon doctors across Europe were advocating heliotherapy as a cure for all sorts of afflictions, such as infectious diseases, wounds, burns, arthritis, rheumatism and nerve damage. Suntans became popular, and many proclaimed the sun to be the long-sought fountain of youth.

Soon doctors across Europe were advocating heliotherapy as a cure for all sorts of afflictions, such as infectious diseases, wounds, burns, arthritis, rheumatism and nerve damage. Suntans became popular, and many proclaimed the sun to be the long-sought fountain of youth.

By this time, scientists had accumulated evidence for the practice as well. Researchers showed that sunlight could kill the bacteria that caused tuberculosis and other infectious diseases.10 Others later proved that ultraviolet light could cure rickets, by creating vitamin D on the skin.11

Researchers showed that sunlight could kill the bacteria that caused tuberculosis and other infectious diseases.10 Others later proved that ultraviolet light could cure rickets, by creating vitamin D on the skin.

Vitamin D and Sunlight

Human skin contains a compound that functions as a precursor to vitamin D, called 7-dehydrocholesterol. When ultraviolet light from the sun penetrates the skin, a specific portion of the light can transform 7-dehydrocholesterol into vitamin D3 by breaking a bond in the precursor molecule. Specifically, it’s the ultraviolet-B portion of the spectrum, which moves at a faster wavelength than its slower cousin, ultraviolet-A rays. Simply put, sunlight breaks a bond in a molecule on the skin and then the body uses the new, sun-altered compound for biochemical purposes. The best-known benefit of sunlight is its ability to boost the body’s vitamin D supply. Most cases of vitamin D deficiency are due to lack of outdoor sun exposure.

At least 1,000 different genes governing virtually every tissue in the body are now thought to be regulated by 1,25-dihydroxyvitamin D3(1,25[OH]D), the active form of the vitamin, including several involved in calcium metabolism and neuromuscular and immune system functioning. The efficiency of production depends on the number of ultraviolet-B photons that penetrate the skin, a process that can be curtailed by clothing, excess body fat, sunscreen, and the skin pigment melanin.

Over the past three decades, several thousand articles have been published about the health benefits of sunlight exposure and optimal vitamin D status via ultraviolet exposure, diet and supplements. Observations have been supported by retrospective studies that link low circulating levels of 25-hydroxyvitamin D, a measure of vitamin D status, with an increased risk of a vast array of detrimental conditions, including type 2 diabetes mellitus, infectious diseases, cancer, multiple sclerosis and neurocognitive dysfunction.

Human skin contains a compound that functions as a precursor to vitamin D, called 7-dehydrocholesterol. When ultraviolet light from the sun penetrates the skin, a specific portion of the light can transform 7-dehydrocholesterol into vitamin D3 by breaking a bond in the precursor molecule.

By World War II, the popularity of sunbathing and heliotherapy gradually declined. Newly discovered antibiotics were thought more powerful against germs than sunlight. The era of pharmaceuticals was in full bloom by the 1950s, and heliotherapy was virtually forgotten.

Phototherapy

Over the last century, as sunbathing became less popular, phototherapy continued to play a pivotal role in the treatment of dermatologic diseases. In the middle of the 20th century, advancements in ultraviolet-B light therapy expanded treatment options for patients with psoriasis. Now, phototherapy, either as monotherapy or combined with other modalities, is used increasingly in the outpatient management of inflammatory dermatoses such as psoriasis, keratinizing disorders such as pityriasis lichenoides chronica and keratosis pilaris, and the eczemas, particularly atopic dermatitis.

In the 1970s, photochemotherapy (i.e. using psoralen as a photosensitizer in combination with ultraviolet-A radiation [PUVA]) made its debut. PUVA became established in the treatment of skin diseases in the last quarter of the 20th century. More recent advances in the past few decades that have revolutionized phototherapy include narrowband ultraviolet-B, laser and other targeted phototherapy, and photodynamic therapy. Another new light source, UVA1, has been developed in the last decade. In the absence of adequate therapeutic action spectra research data, the empirical use of UVA1 (340-400 nm) has shown these wavelengths to be beneficial in the treatment of atopic dermatitis. Two types of UVA1 emission sources currently are in use: a lower dose output fluorescent tube, and a high output filtered metal halide source, particularly popular in Germany, with treatments of up to 130 joules UVA/cm2 possible.

The Advent of Sun Avoidance

Nowadays, the sundial of heliotherapy has moved in the opposite direction. Most public health messages of the last several decades have focused on the hazards of too much sun exposure. Exposure to sunlight is actively discouraged for fear of skin cancer, and contemporary lifestyles are associated with long hours spent under artificial light indoors.

Ultraviolet radiation penetrates deeply into the skin, where it can contribute to skin cancer indirectly via generation of DNA-damaging molecules such as hydroxyl and oxygen radicals. Both forms of ultraviolet light (A and B) can damage collagen fibers, accelerate aging of the skin, and increase the risk of skin cancers. Excessive sun exposure can also cause cataracts and diseases aggravated by UV radiation-induced immunosuppression such as reactivation of some latent viruses.

Ultraviolet radiation penetrates deeply into the skin, where it can contribute to skin cancer indirectly via generation of DNA-damaging molecules such as hydroxyl and oxygen radicals. Both forms of ultraviolet light (A and B) can damage collagen fibers, accelerate aging of the skin, and increase the risk of skin cancers.

The World Health Organization's International Agency for Research on Cancer recommends avoiding outdoor activities at midday, wearing clothing to cover the whole body, and daily use of sunscreen on usually exposed skin.12 Several organizations began advocating "Slip, Slop, Slap, Seek, Slide." “Slip on a shirt, Slop on the 50+ sunscreen, Slap on a hat, Seek shade or shelter, Slide on some glasses used to block out sun.”13 The U.S. Surgeon General issued a Call to Action focused on reducing ultraviolet exposure, whether from indoor ultraviolet or from the sun.14 These recommendations are understandable from the viewpoint of preventing new cases of skin cancer each year, but they neglect the fact that we have a long cross-cultural history of appreciation of the sun and use of the sun’s radiation for healing purposes.

Many dermatologists now recommend spending small amounts of time in the sun without sun protection to ensure adequate production of vitamin D. Adequate amounts can be produced with moderate sun exposure to the face, arms and legs, averaging 10 to 30 minutes several times per week without sunscreen. People with darker skin may need a little more than this. Exposure time should depend on how sensitive your skin is to sunlight. Vitamin D levels should be periodically checked, and D-3 supplementation may be necessary, even with moderate sun exposure.

While there is incontrovertible evidence that ultraviolet radiation is a significant predisposing factor for skin cancers15, a growing body of data suggest numerous general health benefits are brought about by sunlight. Particularly, the fact that increased sun exposure has been associated with protection from several different types of cancer16, 17, 18, 19, 20, 21, 22, 23, 24, 25, diabetes26, multiple sclerosis27, and numerous other dseases.28, 29, 30, 31 In fact, the current policy of sun avoidance is creating probable harm for the general population.

Sun exposure opinions are slowly changing. The National Academy of Sciences recently assembled an international group of medical experts from different fields to discuss sun safety. The 2018 report from that meeting, published in JAMA Dermatology, stated that “although the harms associated with overexposure outweigh the benefits, the beneficial effects of ultraviolet radiation exposure should not be ignored in developing new sun safety guidelines.”32

Sunlight and Nitric Oxide

Research now shows that sunlight produces physiological responses well beyond the production of vitamin D. Specifically, it is observed that when the skin is exposed to the ultraviolet-A portion of the solar spectrum, which ranges from 315 nm to 400 nm, nitric oxide (NO) is released in the body. Nitric oxide is a potent vasodilator and is a widespread signaling molecule that participates in virtually every cellular and organ function in the body. It is involved in the maintenance of vascular tone, neurotransmitter function in both the central and peripheral nervous systems, and mediation of cellular defense. In addition, NO interacts with mitochondrial systems to regulate cell respiration and to augment the generation of reactive oxygen species, thus triggering mechanisms of cell survival or death. Thus, when the skin is stimulated with ultraviolet-A radiation, nitric oxide is released, stimulating vasodilation and lowering blood pressure.33

A 2014 study showed that during active exposure to ultraviolet-A, diastolic blood pressure fell by roughly 5 mm Hg and remained lower for 30 minutes after exposure.33 Several other studies have also demonstrated that exposure with ultraviolet-A leads to a sustained reduction in blood pressure.34, 35, 36, 37